tactic publications: research and clinical advancements

Published on 30/03/2026 17:45

About tactic publications

This page showcases a selection of publications and presentations stemming from the TACTIC (Trauma Anesthesia and Critical Care) research group. The group focuses on advancing understanding and improving outcomes in trauma patients, particularly in areas of coagulation, resuscitation, and critical care. The listed works cover a wide range of topics, demonstrating TACTIC's commitment to rigorous scientific investigation and clinical translation.

Coagulation and trauma

Several publications explore the complex relationship between trauma and coagulation. Research investigates trauma-induced coagulopathy (TIC) and its impact on mortality, highlighting the importance of clinical assessment. Studies also examine the roles of FXIa, platelet polyphosphate, and tissue factor in the coagulation cascade following injury, identifying potential therapeutic targets. The TACTIC team underscores the critical need for personalized coagulation profiling in disease risk management.

Resuscitation strategies

The COMBAT trial results are presented, detailing the initial experience with a randomized clinical trial assessing plasma-based resuscitation in traumatic hemorrhagic shock. This research aims to refine resuscitation protocols and improve survival rates in critically injured patients. Furthermore, explorations into the impact of alcohol on coagulation in trauma patients offer valuable insights into patient management considerations.

Inflammation and injury

Research focuses on the inflammatory responses following trauma, including investigations into caspase 1-mediated pathways and the role of histones in red blood cell function. These studies highlight the intricate interplay between coagulation, inflammation, and overall patient outcomes in the traumatic setting. The research also explores the impact of obesity and hyperfibrinolysis on trauma patients.

Thrombin generation and hemostatic models

The group's work extends to developing dynamic models for thrombin generation, aiming to better understand the balance between pro- and anticoagulant factors. This research contributes to a more refined understanding of hemostatic processes and their implications for disease development and treatment strategies. Models for thrombin generation and risk assessment are detailed, demonstrating the group's contribution to the field.

Specific research findings

  • Clinical assessment of trauma-induced coagulopathy and its contribution to postinjury mortality.
  • Investigation of FXIa and platelet polyphosphate as therapeutic targets.
  • The role of tissue factor in mediating coagulation and coagulopathy after injury.
  • Development of individualized coagulation profiling for disease risk.
  • Evaluation of plasma-based resuscitation in traumatic hemorrhagic shock.
  • Studies on polyphosphate acceleration of factor V activation.
  • Contributions to understanding thromboinflammatory microparticles.

Future directions

TACTIC continues to pursue innovative research avenues, including investigations into bile acid effects on platelet inhibition and fibrinolysis. The group remains dedicated to translating scientific discoveries into improved clinical practice and better outcomes for trauma patients. Their ongoing efforts focus on a comprehensive understanding of the complex hemostatic and inflammatory processes involved in traumatic injury.